Safety LaRon Landry and linebacker Brian Orakpo are both questionable for Sunday's game against the Arizona Cardinals.
Head coach Mike Shanahan said on Friday that both Landry and Orakpo would likely be "game day decisions."
Both were limited in Friday's practice and participated in individual drills.
Landry continues to recover from a hamstring injury he suffered midway through preseason. If he is not able to play on Sunday, then Reed Doughty is expected to start in his place for the second straight week.
Orakpo has been slowed by an ankle injury he suffered in the season opener against the New York Giants.
Rob Jackson could be called on to start if Orakpo's injury keeps him out of Sunday's game.
Shanahan said earlier this week he had confidence in Jackson.
"Rob has done a good job since he's been here. I'm sure if Rob starts, he'll do a good job," Shanahan said. "He did a good job for us last year on the scout team and he's becoming more comfortable with the defense."