Wide receiver Jamison Crowder returned to the practice field on Thursday, but after initially being listed as questionable Friday, he has been ruled out for Sunday's game against the Buccaneers.
It is progress for the team's slot receiver, who will miss his fifth game with an ankle sprain.
"He did a little bit more today. He did pretty good," Gruden said Friday.
Only two other players will be officially out for Sunday. Left tackle Trent Williams will miss his second consecutive game recovering from thumb surgery and running back Chris Thompson will not travel, as he continues to battle back from a rib injury he sustained against the Giants.
Cornerback Quinton Dunbar (shin), who after returning to game action last week against the Falcons had setbacks throughout the contest, didn't practice this week but is questionable for Sunday.
"He didn't do much," Gruden said. "He was on the side and did some work on his leg yesterday. Today we want him to rest and then we'll test it out tomorrow."
Losing him would be a tough one for the Redskins, which will need some rookie corners to step up against another big passing attack in Tampa.
"It'll be a challenge very much so," Gruden said. "Danny [Johnson] and [Greg] Stroman are going to have to step it up and Fabian [Moreau], will maybe have to move out to corner in some base but we'll see. I think Stroman has some pretty good experience and Danny got some experience last week so strap it up and play."
And while the Redskins were dealt some serious blows earlier in the week, learning that guards Shawn Lauvao, Brandon Scherff and wide receiver Paul Richardson Jr. needed season-ending surgery, they may be down another starting offensive lineman.
Right tackle Morgan Moses, already battling an elbow injury, is listed as questionable for Sunday's game with a knee injury he also suffered against the Falcons.
"Yeah, he did more team today and fought through it, did a good job," Gruden sauid. "With all these guys that are questionable, it'll depend on how they're feeling tonight and tomorrow."
The Redskins brought in three offensive linemen this week to help bandage the gap left by Lauvao and Scherff, but the team could potentially have two new faces see starting action on Sunday if Moses can't go. Gruden said Friday that rookie tackle Geron Christian Sr. would likely step up in his place.
"Well, they look good in practice," Gruden said of the new linemen. "They've done a great job. Hats off to the coaches. Coach Callahan [Assistant Head Coach/Offensive Line] and Phil [Assistant Offensive Line Coach Phil Rauscher] obviously for getting them ready to go. But we'll see. I think playing in 83 degree heat for the first time could take its toll on them, but we'll have some other guys available if it is an issue. We have to wait and see, but I'm optimistic that they've picked it up mentally. That's half the battle. Now physically on a 7, 8, 10 play drive, we'll see where they're at."